locus tag: FAM19471-i1-1.1_000886 genome: FAM19471-i1-1.1
species: Limosilactobacillus fermentum taxid: 1613

Annotations

Type Name Description Pathways
Gene Product
 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha
Gene Code
 pdhA
KEGG reaction
 R10997 2-(alpha-Hydroxypropyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> Enzyme N6-(S-propyldihydrolipoyl)lysine + Thiamin diphosphate kornec00640 kornec01100
KEGG reaction
 R10996 2-Oxobutanoate + Thiamin diphosphate <=> 2-(alpha-Hydroxypropyl)thiamine diphosphate + CO2 kornec00640 kornec01100
KEGG reaction
 R07604 2-Methyl-1-hydroxybutyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + Thiamin diphosphate kornec00280
KEGG reaction
 R07603 (S)-3-Methyl-2-oxopentanoic acid + Thiamin diphosphate <=> 2-Methyl-1-hydroxybutyl-ThPP + CO2 kornec00280
KEGG reaction
 R07602 3-Methyl-1-hydroxybutyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine + Thiamin diphosphate kornec01100 kornec00280
KEGG reaction
 R07601 4-Methyl-2-oxopentanoate + Thiamin diphosphate <=> 3-Methyl-1-hydroxybutyl-ThPP + CO2 kornec01100 kornec00280
KEGG reaction
 R07600 2-Methyl-1-hydroxypropyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + Thiamin diphosphate kornec00280
KEGG reaction
 R07599 3-Methyl-2-oxobutanoic acid + Thiamin diphosphate <=> 2-Methyl-1-hydroxypropyl-ThPP + CO2 kornec00280
KEGG reaction
 R03270 2-(alpha-Hydroxyethyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + Thiamin diphosphate kornec00010 kornec00620 kornec00020
KEGG reaction
 R01699 pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating); Pyruvate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
KEGG reaction
 R00209 pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex; Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+ kornec01200 kornec01100 kornec01110 kornec01120
KEGG reaction
 R00014 pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating); Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2 kornec00010 kornec00620 kornec00020
Ortholog
 N0.HOG0000683 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha
KEGG gene
 K00166 BCKDHA, bkdA1; 2-oxoisovalerate dehydrogenase E1 component alpha subunit [EC:1.2.4.4] kornec00640 kornec01100 kornec00280 kornec01110
KEGG gene
 K00161 PDHA, pdhA; pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1] kornec00010 kornec05230 kornec01200 kornec01100 kornec00620 kornec04066 kornec01110 kornec01120 kornec00020 kornec04922
Eggnog Protein
 EP:pdhA
Eggnog Ortholog
 EO:1TQDG
Eggnog Description
 ED:Dehydrogenase E1 component
EC Number
 EC:1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); 2-oxoisocaproate dehydrogenase; 2-oxoisovalerate (lipoate) dehydrogenase; 3-methyl-2-oxobutanoate dehydrogenase (lipoamide); 3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating); alpha-keto-alpha-methylvalerate dehydrogenase; alpha-ketoisocaproate dehydrogenase; alpha-ketoisocaproic dehydrogenase; alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase; alpha-ketoisovalerate dehydrogenase; alpha-oxoisocaproate dehydrogenase; BCKDH (ambiguous); BCOAD; branched chain keto acid dehydrogenase; branched-chain (-2-oxoacid) dehydrogenase (BCD); branched-chain 2-keto acid dehydrogenase; branched-chain 2-oxo acid dehydrogenase; branched-chain alpha-keto acid dehydrogenase; branched-chain alpha-oxo acid dehydrogenase; branched-chain keto acid dehydrogenase; branched-chain ketoacid dehydrogenase; dehydrogenase, 2-oxoisovalerate (lipoate); dehydrogenase, branched chain alpha-keto acid kornec00640 kornec01100 kornec00280 kornec01110
EC Number
 EC:1.2.4.1 pyruvate dehydrogenase (acetyl-transferring); pyruvate decarboxylase (ambiguous); pyruvate dehydrogenase (ambiguous); pyruvate dehydrogenase (lipoamide); pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating); pyruvic acid dehydrogenase; pyruvic dehydrogenase (ambiguous) kornec00010 kornec01100 kornec00620 kornec01110 kornec01120 kornec00020

Occurs in the following pathway maps:

Pathway Description
kornec00010 Glycolysis / Gluconeogenesis
kornec00020 Citrate cycle (TCA cycle)
kornec00280 Valine, leucine and isoleucine degradation
kornec00620 Pyruvate metabolism
kornec00640 Propanoate metabolism
kornec01100 Metabolic pathways
kornec01110 Biosynthesis of secondary metabolites
kornec01120 Microbial metabolism in diverse environments
kornec01200 Carbon metabolism
kornec04066 HIF-1 signaling pathway
kornec04922 Glucagon signaling pathway
kornec05230 Central carbon metabolism in cancer

Sequences

Nucleotide sequence (GC-content: 50.5 %):

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ATGAAAAAGTTAGACTTTGAAAGCCTTAAGCACAACCCTGAGTACGAGGTTCTTCAGGTCCTCGGTACTGATGGCAAGGTTGTCAATGAGGACTTAATGCCAGACCTAACCGATGATCAATTGGTAGATCTGTTTAAGCAAATGATTTGGTCCCGATTAGTTGGTGACCAAACTGCTAAGCTTAGCCGTCAAGGCCGGTTAGGTTTCTTCGCCCCAACTGCCGGGGAAGAAGCCAGCCAAATGGGTTCCAACTTCGCGATGACCAAGGACGACTTCCTCTTGGGTGCATATCGTGACGTCCCACAATTGATCAAGCACGGTCTGTCCTTAGCTAAGGGCTTCATGTGGTCTAAGGGTCACTACAACGCTAACGACTACCCAGAAGAATTGAACGCTTTGCCACCACAAATCATCATTGGTGCTCAATACGCTCAAACTGCTGGGGTTGCCCTTGGGATCAAGCTCAACGGCGACAAGAAGGTTGCCTACACCTACACTGGTGACGGTGGTACTTCGCAGGGTGACTTCTACGAAGGGATTAACTTCGCAGGGGCTTACCAAGCACCGGCTGTCTTCTTTGTTCAAAACAACGGTTACGCTATCTCCGTTCCACGGAAGCTGCAAACCGCTGCTCCAACCCTGGCTCAAAAGGGTGTGGCTGCCGGAATTCCTTCCATCGTAGTTGACGGGATGGACGCCCTGGCGGTTTATGCTGCTGCTAAGCAAGCACGTGACTACGCCGTTGAAGGTAATGGTCCAGTGATCATCGAAACGCTGACTTACCGTTACGGACCACACACCCTTTCTGGTGACGACCCAACCCGTTACCGGACTAAGGAAGAAGAAGACGAATGGCACGCAAAGGACCCACTGGTTCGGATGCGTAAGTTCCTGACTGACAAGGGTCTTTGGGACGACGCCAGGGAAGAAGCCTACAACGCTGAAGTGGCTAAGGAAATCGACGACGCTATCAAGGAAGTTGAAAGCCAACCAGCTCAAAAGGCATCTGACTTCTTGAAGTTCGAATTTGTCGACACTCCAGGTGCTATTCAACGTGAAATCGATGAGTACGAAGAAAAGGAGGCCAAATAA

Protein sequence:

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MKKLDFESLKHNPEYEVLQVLGTDGKVVNEDLMPDLTDDQLVDLFKQMIWSRLVGDQTAKLSRQGRLGFFAPTAGEEASQMGSNFAMTKDDFLLGAYRDVPQLIKHGLSLAKGFMWSKGHYNANDYPEELNALPPQIIIGAQYAQTAGVALGIKLNGDKKVAYTYTGDGGTSQGDFYEGINFAGAYQAPAVFFVQNNGYAISVPRKLQTAAPTLAQKGVAAGIPSIVVDGMDALAVYAAAKQARDYAVEGNGPVIIETLTYRYGPHTLSGDDPTRYRTKEEEDEWHAKDPLVRMRKFLTDKGLWDDAREEAYNAEVAKEIDDAIKEVESQPAQKASDFLKFEFVDTPGAIQREIDEYEEKEAK

GenBank Info

gene - pdhA
locus_tag - FAM19471-i1-1.1_000886
inference - COORDINATES: similar to AA sequence:RefSeq:WP_014562492.1
note - Derived by automated computational analysis using gene prediction method: Protein Homology.
codon_start - 1
transl_table - 11
product - pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha
protein_id - extdb:FAM19471-i1-1.1_000886

Gene locus (click to toggle display options) expand

Located on scaffold FAM19471-i1-1_scf0013

Update range to 10000 bp
FAM19471-i1-1.1_000885
FAM19471-i1-1.1_000887