locus tag: FAM19038-p1-1.1_002611 genome: FAM19038-p1-1.1
species: Acidipropionibacterium thoenii DSM 20276 taxid: 1122998

Annotations

Type Name Description Pathways
Gene Product
 thiamine phosphate synthase
Gene Code
 thiE
KEGG reaction
 R10712 2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate 2-methyl-4-aminopyrimidine-5-methenyltransferase; 4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate + 2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate <=> Thiamin monophosphate + Diphosphate + CO2 kornec00730 kornec01100 kornec01240
KEGG reaction
 R04509 ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase; ATP + 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine <=> ADP + 4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate kornec00730 kornec01100 kornec01240
KEGG reaction
 R03471 ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase; ATP + 4-Amino-5-hydroxymethyl-2-methylpyrimidine <=> ADP + 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine kornec00730 kornec01100 kornec01240
KEGG reaction
 R03223 2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)-thiazole 2-methyl-4-aminopyridine-5-methenyltransferase; 4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate + 4-Methyl-5-(2-phosphooxyethyl)thiazole <=> Diphosphate + Thiamin monophosphate kornec00730 kornec01100 kornec01240
Ortholog
 N0.HOG0000765 thiamine phosphate synthase
KEGG gene
 K14153 thiDE; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase [EC:2.7.1.49 2.7.4.7 2.5.1.3] kornec00730 kornec01100 kornec01240
KEGG gene
 K00788 thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3] kornec00730 kornec01100 kornec01240
Gene Ontology
 GO:1901576 organic substance biosynthetic process
Gene Ontology
 GO:1901566 organonitrogen compound biosynthetic process
Gene Ontology
 GO:1901564 organonitrogen compound metabolic process
Gene Ontology
 GO:1901362 organic cyclic compound biosynthetic process
Gene Ontology
 GO:1901360 organic cyclic compound metabolic process
Gene Ontology
 GO:0072528 pyrimidine-containing compound biosynthetic process
Gene Ontology
 GO:0072527 pyrimidine-containing compound metabolic process
Gene Ontology
 GO:0071704 organic substance metabolic process
Gene Ontology
 GO:0046483 heterocycle metabolic process
Gene Ontology
 GO:0044464 obsolete cell part
Gene Ontology
 GO:0044424 obsolete intracellular part
Gene Ontology
 GO:0044283 small molecule biosynthetic process
Gene Ontology
 GO:0044281 small molecule metabolic process
Gene Ontology
 GO:0044272 sulfur compound biosynthetic process
Gene Ontology
 GO:0044271 cellular nitrogen compound biosynthetic process
Gene Ontology
 GO:0044249 cellular biosynthetic process
Gene Ontology
 GO:0044237 cellular metabolic process
Gene Ontology
 GO:0042724 thiamine-containing compound biosynthetic process
Gene Ontology
 GO:0042723 thiamine-containing compound metabolic process
Gene Ontology
 GO:0042364 water-soluble vitamin biosynthetic process
Gene Ontology
 GO:0034641 cellular nitrogen compound metabolic process
Gene Ontology
 GO:0019438 aromatic compound biosynthetic process
Gene Ontology
 GO:0018130 heterocycle biosynthetic process
Gene Ontology
 GO:0017144 drug metabolic process
Gene Ontology
 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
Gene Ontology
 GO:0016740 transferase activity
Gene Ontology
 GO:0009987 cellular process
Gene Ontology
 GO:0009228 thiamine biosynthetic process
Gene Ontology
 GO:0009110 vitamin biosynthetic process
Gene Ontology
 GO:0009058 biosynthetic process
Gene Ontology
 GO:0008152 metabolic process
Gene Ontology
 GO:0008150 biological_process
Gene Ontology
 GO:0006807 nitrogen compound metabolic process
Gene Ontology
 GO:0006790 sulfur compound metabolic process
Gene Ontology
 GO:0006772 thiamine metabolic process
Gene Ontology
 GO:0006767 water-soluble vitamin metabolic process
Gene Ontology
 GO:0006766 vitamin metabolic process
Gene Ontology
 GO:0006725 cellular aromatic compound metabolic process
Gene Ontology
 GO:0005737 cytoplasm
Gene Ontology
 GO:0005623 obsolete cell
Gene Ontology
 GO:0005622 intracellular anatomical structure
Gene Ontology
 GO:0005575 cellular_component
Gene Ontology
 GO:0004789 thiamine-phosphate diphosphorylase activity
Gene Ontology
 GO:0003824 catalytic activity
Gene Ontology
 GO:0003674 molecular_function
Eggnog Protein
 EP:thiE
Eggnog Ortholog
 EO:2GKCN
Eggnog Description
 ED:Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
EC Number
 EC:2.7.4.7 phosphooxymethylpyrimidine kinase; hydroxymethylpyrimidine phosphokinase; ATP:4-amino-2-methyl-5-phosphooxymethylpyrimidine phosphotransferase; ATP:(4-amino-2-methylpyrimidin-5-yl)methyl-phosphate phosphotransferase; phosphomethylpyrimidine kinase kornec00730 kornec01100
EC Number
 EC:2.7.1.49 hydroxymethylpyrimidine kinase; hydroxymethylpyrimidine kinase (phosphorylating) kornec00730 kornec01100
EC Number
 EC:2.5.1.3 thiamine phosphate synthase; thiamine phosphate pyrophosphorylase; thiamine monophosphate pyrophosphorylase; TMP-PPase; thiamine-phosphate diphosphorylase; thiE (gene name); TH1 (gene name); THI6 (gene name); 2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase; 4-amino-2-methyl-5-diphosphomethylpyrimidine:2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate 4-amino-2-methylpyrimidine-5-methenyltransferase (decarboxylating) kornec00730 kornec01100

Occurs in the following pathway maps:

Pathway Description
kornec00730 Thiamine metabolism
kornec01100 Metabolic pathways
kornec01240 Biosynthesis of cofactors

Sequences

Nucleotide sequence (GC-content: 71.9 %):

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ATGGATCTGGGCGTCTACCTGGTGACCGACCCCCGGATGTGCGCCGACAGGGGGGTGTCCCAGACCGTCGCCGCCGCGGTAGCCGGCGGGGTGCGCACCGTGCAGATCCGCGACAAGAGCTGTTCTGCCACCGACTTCTTAGCCCTGGTGGAGGAGGTGGTCGAGACGGTGGCCGGTCGGGCCATGGTGGTGGTCAATGACCGGCTCGACGTGGTGCGCACCGCCCGGGAGCGCGGAGTCGGGGTCGACGGCGTCCACCTCGGTCAGGGCGACGCCGATCCCCGGGTGGCCCGCGAGCAGCTCGGCCCCGATGCGGTGATCGGTCTGACCGCCGACCATGCGGCACATCTGGCCGCGGTGGAGTCCTGGCCGGCCGGGACGATCGACTACCTGGGAGTCGGTGTGATCCACGACACCAGCACCAAGCTCGACCACCCGCCGGTGCTGGGAATCGACGGGTTCGCCCGGTTCACCGCCGCCTCACCGGTCCCCACAGTCGCCATCGGGGGAATCTCGCGCGACGATCTGGCCGGACTGCGCCGGGCCGGGGCATCGGGTGCGGCGGTCGTCTCGGCGATCTGCGCCGCCGAGGATCCGCAGGAGGCCGCCCGCGATCTGGTGGAGGCCTGGCAGCAAGCTCCCGTGCCCGCCGGGAGTCTGGCGAGGAGCTGA

Protein sequence:

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MDLGVYLVTDPRMCADRGVSQTVAAAVAGGVRTVQIRDKSCSATDFLALVEEVVETVAGRAMVVVNDRLDVVRTARERGVGVDGVHLGQGDADPRVAREQLGPDAVIGLTADHAAHLAAVESWPAGTIDYLGVGVIHDTSTKLDHPPVLGIDGFARFTAASPVPTVAIGGISRDDLAGLRRAGASGAAVVSAICAAEDPQEAARDLVEAWQQAPVPAGSLARS

GenBank Info

gene - thiE
locus_tag - FAM19038-p1-1.1_002611
EC_number - 2.5.1.3
inference - COORDINATES: similar to AA sequence:RefSeq:WP_019618964.1
note - Derived by automated computational analysis using gene prediction method: Protein Homology.
codon_start - 1
transl_table - 11
product - thiamine phosphate synthase
protein_id - extdb:FAM19038-p1-1.1_002611

Gene locus (click to toggle display options) expand

Located on scaffold FAM19038-p1-1_scf0001

Update range to 10000 bp

Cellular location expand

Responsible annotations:
SL-0229: GO:0005622 intracellular anatomical structure
SL-0086: GO:0005737 cytoplasm
FAM19038-p1-1.1_002610
FAM19038-p1-1.1_002612