# Average Nucleotide Identity (ANI) Compute pairwise genome similarity and view it as an interactive heatmap matrix. **To start:** select **multiple genomes** in the **Genomes** box and click **Submit**. (Tip: use [**magic strings**](https://docs.abrinca.com/arx/guides/magic-strings/) to select genomes.) Choose an **engine**: *gendiscal* is fast and recommended for most use cases; *pyani-plus* offers additional methods (fastANI, ANIb, ANIm, dnadiff). [Guide →](https://docs.abrinca.com/arx/guides/ani/)