locus tag: FAM19471-i1-1.1_000883 genome: FAM19471-i1-1.1
species: Limosilactobacillus fermentum taxid: 1613

Annotations

Type Name Description Pathways
Gene Code
 lpdA
Gene Product
 dihydrolipoyl dehydrogenase
KEGG reaction
 R08549 2-Oxoglutarate dehydrogenase complex; 2-Oxoglutarate + CoA + NAD+ <=> Succinyl-CoA + CO2 + NADH + H+ kornec01200 kornec01100 kornec01110 kornec01120
KEGG reaction
 R07618 enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase; Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+ kornec00010 kornec00640 kornec01100 kornec00280 kornec00620 kornec01240 kornec01110 kornec00020
KEGG reaction
 R03815 dihydrolipoylprotein:NAD+ oxidoreductase; Dihydrolipoylprotein + NAD+ <=> Lipoylprotein + NADH + H+ kornec00260
KEGG reaction
 R01698 Dihydrolipoamide:NAD+ oxidoreductase; Dihydrolipoamide + NAD+ <=> Lipoamide + NADH + H+
KEGG reaction
 R01221 glycine synthase; glycine cleavage system; Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+ kornec01200 kornec01100 kornec00630 kornec01110
KEGG reaction
 R00209 pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex; Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+ kornec01200 kornec01100 kornec01110 kornec01120
Ortholog
 N0.HOG0000539 dihydrolipoyl dehydrogenase
KEGG gene
 K00382 DLD, lpd, pdhD; dihydrolipoamide dehydrogenase [EC:1.8.1.4] kornec00310 kornec00010 kornec01200 kornec00640 kornec01100 kornec00380 kornec00280 kornec00260 kornec00620 kornec00630 kornec01240 kornec01110 kornec01120 kornec00020
Gene Ontology
 GO:1990234 transferase complex
Gene Ontology
 GO:1990204 oxidoreductase complex
Gene Ontology
 GO:1902494 catalytic complex
Gene Ontology
 GO:1901606 alpha-amino acid catabolic process
Gene Ontology
 GO:1901605 alpha-amino acid metabolic process
Gene Ontology
 GO:1901576 organic substance biosynthetic process
Gene Ontology
 GO:1901575 organic substance catabolic process
Gene Ontology
 GO:1901566 organonitrogen compound biosynthetic process
Gene Ontology
 GO:1901565 organonitrogen compound catabolic process
Gene Ontology
 GO:1901564 organonitrogen compound metabolic process
Gene Ontology
 GO:1901363 heterocyclic compound binding
Gene Ontology
 GO:1901362 organic cyclic compound biosynthetic process
Gene Ontology
 GO:1901360 organic cyclic compound metabolic process
Gene Ontology
 GO:1901293 nucleoside phosphate biosynthetic process
Gene Ontology
 GO:1901265 nucleoside phosphate binding
Gene Ontology
 GO:1901137 carbohydrate derivative biosynthetic process
Gene Ontology
 GO:1901135 carbohydrate derivative metabolic process
Gene Ontology
 GO:0106077 histone succinylation
Gene Ontology
 GO:0097159 organic cyclic compound binding
Gene Ontology
 GO:0090407 organophosphate biosynthetic process
Gene Ontology
 GO:0072524 pyridine-containing compound metabolic process
Gene Ontology
 GO:0072522 purine-containing compound biosynthetic process
Gene Ontology
 GO:0072521 purine-containing compound metabolic process
Gene Ontology
 GO:0071704 organic substance metabolic process
Gene Ontology
 GO:0071616 acyl-CoA biosynthetic process
Gene Ontology
 GO:0070013 intracellular organelle lumen
Gene Ontology
 GO:0065008 regulation of biological quality
Gene Ontology
 GO:0065007 biological regulation
Gene Ontology
 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate
Gene Ontology
 GO:0055114 oxidation-reduction process
Gene Ontology
 GO:0055086 nucleobase-containing small molecule metabolic process
Gene Ontology
 GO:0051188 obsolete cofactor biosynthetic process
Gene Ontology
 GO:0051186 obsolete cofactor metabolic process
Gene Ontology
 GO:0050896 response to stimulus
Gene Ontology
 GO:0050662 obsolete coenzyme binding
Gene Ontology
 GO:0050660 flavin adenine dinucleotide binding
Gene Ontology
 GO:0048037 obsolete cofactor binding
Gene Ontology
 GO:0046914 transition metal ion binding
Gene Ontology
 GO:0046872 metal ion binding
Gene Ontology
 GO:0046496 nicotinamide nucleotide metabolic process
Gene Ontology
 GO:0046483 heterocycle metabolic process
Gene Ontology
 GO:0046395 carboxylic acid catabolic process
Gene Ontology
 GO:0046390 ribose phosphate biosynthetic process
Gene Ontology
 GO:0045254 pyruvate dehydrogenase complex
Gene Ontology
 GO:0045252 oxoglutarate dehydrogenase complex
Gene Ontology
 GO:0045250 cytosolic pyruvate dehydrogenase complex
Gene Ontology
 GO:0045240 dihydrolipoyl dehydrogenase complex
Gene Ontology
 GO:0045239 tricarboxylic acid cycle enzyme complex
Gene Ontology
 GO:0044464 obsolete cell part
Gene Ontology
 GO:0044446 obsolete intracellular organelle part
Gene Ontology
 GO:0044445 obsolete cytosolic part
Gene Ontology
 GO:0044444 obsolete cytoplasmic part
Gene Ontology
 GO:0044429 obsolete mitochondrial part
Gene Ontology
 GO:0044428 obsolete nuclear part
Gene Ontology
 GO:0044424 obsolete intracellular part
Gene Ontology
 GO:0044422 obsolete organelle part
Gene Ontology
 GO:0044282 small molecule catabolic process
Gene Ontology
 GO:0044281 small molecule metabolic process
Gene Ontology
 GO:0044272 sulfur compound biosynthetic process
Gene Ontology
 GO:0044271 cellular nitrogen compound biosynthetic process
Gene Ontology
 GO:0044267 cellular protein metabolic process
Gene Ontology
 GO:0044260 cellular macromolecule metabolic process
Gene Ontology
 GO:0044249 cellular biosynthetic process
Gene Ontology
 GO:0044248 cellular catabolic process
Gene Ontology
 GO:0044238 primary metabolic process
Gene Ontology
 GO:0044237 cellular metabolic process
Gene Ontology
 GO:0043648 dicarboxylic acid metabolic process
Gene Ontology
 GO:0043604 amide biosynthetic process
Gene Ontology
 GO:0043603 cellular amide metabolic process
Gene Ontology
 GO:0043543 protein acylation
Gene Ontology
 GO:0043436 oxoacid metabolic process
Gene Ontology
 GO:0043412 macromolecule modification
Gene Ontology
 GO:0043233 organelle lumen
Gene Ontology
 GO:0043231 intracellular membrane-bounded organelle
Gene Ontology
 GO:0043229 intracellular organelle
Gene Ontology
 GO:0043227 membrane-bounded organelle
Gene Ontology
 GO:0043226 organelle
Gene Ontology
 GO:0043170 macromolecule metabolic process
Gene Ontology
 GO:0043169 cation binding
Gene Ontology
 GO:0043168 anion binding
Gene Ontology
 GO:0043167 ion binding
Gene Ontology
 GO:0042802 identical protein binding
Gene Ontology
 GO:0042737 drug catabolic process
Gene Ontology
 GO:0042135 neurotransmitter catabolic process
Gene Ontology
 GO:0042133 neurotransmitter metabolic process
Gene Ontology
 GO:0036211 protein modification process
Gene Ontology
 GO:0036094 small molecule binding
Gene Ontology
 GO:0035384 thioester biosynthetic process
Gene Ontology
 GO:0035383 thioester metabolic process
Gene Ontology
 GO:0034654 nucleobase-containing compound biosynthetic process
Gene Ontology
 GO:0034641 cellular nitrogen compound metabolic process
Gene Ontology
 GO:0034033 purine nucleoside bisphosphate biosynthetic process
Gene Ontology
 GO:0034032 purine nucleoside bisphosphate metabolic process
Gene Ontology
 GO:0034030 ribonucleoside bisphosphate biosynthetic process
Gene Ontology
 GO:0033875 ribonucleoside bisphosphate metabolic process
Gene Ontology
 GO:0033866 nucleoside bisphosphate biosynthetic process
Gene Ontology
 GO:0033865 nucleoside bisphosphate metabolic process
Gene Ontology
 GO:0032991 protein-containing complex
Gene Ontology
 GO:0032787 monocarboxylic acid metabolic process
Gene Ontology
 GO:0031981 nuclear lumen
Gene Ontology
 GO:0031974 membrane-enclosed lumen
Gene Ontology
 GO:0019752 carboxylic acid metabolic process
Gene Ontology
 GO:0019693 ribose phosphate metabolic process
Gene Ontology
 GO:0019637 organophosphate metabolic process
Gene Ontology
 GO:0019538 protein metabolic process
Gene Ontology
 GO:0019464 glycine decarboxylation via glycine cleavage system
Gene Ontology
 GO:0019438 aromatic compound biosynthetic process
Gene Ontology
 GO:0019362 pyridine nucleotide metabolic process
Gene Ontology
 GO:0018335 protein succinylation
Gene Ontology
 GO:0018130 heterocycle biosynthetic process
Gene Ontology
 GO:0017144 drug metabolic process
Gene Ontology
 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
Gene Ontology
 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors
Gene Ontology
 GO:0016651 oxidoreductase activity, acting on NAD(P)H
Gene Ontology
 GO:0016491 oxidoreductase activity
Gene Ontology
 GO:0016054 organic acid catabolic process
Gene Ontology
 GO:0015036 disulfide oxidoreductase activity
Gene Ontology
 GO:0009987 cellular process
Gene Ontology
 GO:0009260 ribonucleotide biosynthetic process
Gene Ontology
 GO:0009259 ribonucleotide metabolic process
Gene Ontology
 GO:0009165 nucleotide biosynthetic process
Gene Ontology
 GO:0009152 purine ribonucleotide biosynthetic process
Gene Ontology
 GO:0009150 purine ribonucleotide metabolic process
Gene Ontology
 GO:0009117 nucleotide metabolic process
Gene Ontology
 GO:0009108 obsolete coenzyme biosynthetic process
Gene Ontology
 GO:0009071 serine family amino acid catabolic process
Gene Ontology
 GO:0009069 serine family amino acid metabolic process
Gene Ontology
 GO:0009063 cellular amino acid catabolic process
Gene Ontology
 GO:0009058 biosynthetic process
Gene Ontology
 GO:0009056 catabolic process
Gene Ontology
 GO:0008270 zinc ion binding
Gene Ontology
 GO:0008152 metabolic process
Gene Ontology
 GO:0008150 biological_process
Gene Ontology
 GO:0006979 response to oxidative stress
Gene Ontology
 GO:0006950 response to stress
Gene Ontology
 GO:0006807 nitrogen compound metabolic process
Gene Ontology
 GO:0006796 phosphate-containing compound metabolic process
Gene Ontology
 GO:0006793 phosphorus metabolic process
Gene Ontology
 GO:0006790 sulfur compound metabolic process
Gene Ontology
 GO:0006753 nucleoside phosphate metabolic process
Gene Ontology
 GO:0006733 obsolete oxidoreduction coenzyme metabolic process
Gene Ontology
 GO:0006732 obsolete coenzyme metabolic process
Gene Ontology
 GO:0006725 cellular aromatic compound metabolic process
Gene Ontology
 GO:0006637 acyl-CoA metabolic process
Gene Ontology
 GO:0006546 glycine catabolic process
Gene Ontology
 GO:0006544 glycine metabolic process
Gene Ontology
 GO:0006520 cellular amino acid metabolic process
Gene Ontology
 GO:0006464 cellular protein modification process
Gene Ontology
 GO:0006164 purine nucleotide biosynthetic process
Gene Ontology
 GO:0006163 purine nucleotide metabolic process
Gene Ontology
 GO:0006139 nucleobase-containing compound metabolic process
Gene Ontology
 GO:0006103 2-oxoglutarate metabolic process
Gene Ontology
 GO:0006090 pyruvate metabolic process
Gene Ontology
 GO:0006086 acetyl-CoA biosynthetic process from pyruvate
Gene Ontology
 GO:0006085 acetyl-CoA biosynthetic process
Gene Ontology
 GO:0006084 acetyl-CoA metabolic process
Gene Ontology
 GO:0006082 organic acid metabolic process
Gene Ontology
 GO:0005829 cytosol
Gene Ontology
 GO:0005759 mitochondrial matrix
Gene Ontology
 GO:0005739 mitochondrion
Gene Ontology
 GO:0005737 cytoplasm
Gene Ontology
 GO:0005654 nucleoplasm
Gene Ontology
 GO:0005634 nucleus
Gene Ontology
 GO:0005623 obsolete cell
Gene Ontology
 GO:0005622 intracellular anatomical structure
Gene Ontology
 GO:0005575 cellular_component
Gene Ontology
 GO:0005515 protein binding
Gene Ontology
 GO:0005488 binding
Gene Ontology
 GO:0004148 dihydrolipoyl dehydrogenase activity
Gene Ontology
 GO:0003824 catalytic activity
Gene Ontology
 GO:0003674 molecular_function
Gene Ontology
 GO:0001505 regulation of neurotransmitter levels
Gene Ontology
 GO:0000166 nucleotide binding
Eggnog Protein
 EP:lpdA
Eggnog Ortholog
 EO:1TP1W
Eggnog Description
 ED:Dehydrogenase
EC Number
 EC:1.8.1.4 dihydrolipoyl dehydrogenase; LDP-Glc; LDP-Val; dehydrolipoate dehydrogenase; diaphorase; dihydrolipoamide dehydrogenase; dihydrolipoamide:NAD+ oxidoreductase; dihydrolipoic dehydrogenase; dihydrothioctic dehydrogenase; lipoamide dehydrogenase (NADH); lipoamide oxidoreductase (NADH); lipoamide reductase; lipoamide reductase (NADH); lipoate dehydrogenase; lipoic acid dehydrogenase; lipoyl dehydrogenase; protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase kornec00310 kornec00010 kornec00640 kornec01100 kornec00380 kornec00280 kornec00260 kornec00620 kornec01110 kornec01120 kornec00020

Occurs in the following pathway maps:

Pathway Description
kornec00010 Glycolysis / Gluconeogenesis
kornec00020 Citrate cycle (TCA cycle)
kornec00260 Glycine, serine and threonine metabolism
kornec00280 Valine, leucine and isoleucine degradation
kornec00310 Lysine degradation
kornec00380 Tryptophan metabolism
kornec00620 Pyruvate metabolism
kornec00630 Glyoxylate and dicarboxylate metabolism
kornec00640 Propanoate metabolism
kornec01100 Metabolic pathways
kornec01110 Biosynthesis of secondary metabolites
kornec01120 Microbial metabolism in diverse environments
kornec01200 Carbon metabolism
kornec01240 Biosynthesis of cofactors

Sequences

Nucleotide sequence (GC-content: 51.3 %):

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ATGGTTGTTGGTGATTACGCAATTGATTTAGACACGATTGTCATCGGTTCCGGCCCTGGTGGGTACGTGGCAGCCATCCACGCTGCTGAACTGGGCCAAAAGGTGGCCGTGATCGAAAAGGAAAACACTTTAGGTGGGGTCTGCTTAAACGTTGGTTGTATCCCGTCCAAGGCGCTGATCCAAGTTTCTGAAAACTACCGGACGGCCCTCGAAAACGAAGACGAAGGAATTTCCGCATCCGACGTTAAGTTAGACTGGGCTAAGGTACAAGAATTCCGTGCGGGCGTCGTTAACAAGATGACCAACGGGGTTTCCTACCTCTTCAAGAAGAACAAGATTGATGTGATTCACGGGGTGGCCTTCTTAAAGACCGACCACAGCTTACGGGTAATTGACGGCGAAAACGCCCAAACTTACACCTTCAAGCACCTGATTATCGCGACTGGTTCTCACCCAATTGAAATTCCTGGCTTCAAGTTTGGTGGCCGAGTGATCGATTCCACTGGGGTTCTGGAATTAAAGGAATTACCAAAGGAACTGGTTATCATCGGTGGGGGTTACATCGGTAGTGAATTAGCCGGCGCGTACGCTCGCTTCGGGACTCACGTTACGATCCTCGAAGGGACCGACTCAATCTTAAATGCCTACGAAAAGGACTTAGTTAAGATTACCGAAAAGAAGTTCAAGGAACTGGGTGTCACGGTCATTACTAAGGCCATGGCTAAGGAAGCTAAGGATACTGGTGACGCCGTTGAAGTCTCCTACGAACAAGACGGTAAGGTGAACACGATCAAGGCTGATTACGTTGCCGTAGCAGTTGGTCGGAAGCCAAACACCAAGGACATGGGTCTGGAACAAGTTGGGATTGAAACGACTGACCGCGGCCTGATCAAGGTTGACGCTCAAGGTCGGACCAACAAGGAAGATATCTTTGCCATTGGTGACATCGTTGCCGGGGCTGCCTTGGCACACAAGGCTTCCTACGAAGGTAAGATTGCTGCTGAAGCGATTGCCGGGCAATCCTCAGTGGTTGACTACCGGGCAATGCCAGCCGTATGTTACGTGGACCCTGAAATTGCGACGACCGGTTTAACGGCCGCTCAAGCAAAGGAACAAGGCTTAGACGTTAAGGCTTCCAAGTTCCCATTCTCCGCAAACGGGCGGGCAACTTCTAAGAAGGCAACTGATGGTTTCGTTCGCCTGGTTTCCTTAAAGGACAGCGGCGTAATTGTGGGTGCCCAAATTATTGGGGACAGTGCCTCCGACATGATCAGTGAATTGACGCTGGCCATCGAATCCGGGAGCACCGTGGAAGACATCGCTCTGACGATCCACCCACACCCATCCCTGTCTGAAGCCGTAATGGACGCAGCTGACGTGGCCCTTGGCTTCCCAACTAACATCTAA

Protein sequence:

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MVVGDYAIDLDTIVIGSGPGGYVAAIHAAELGQKVAVIEKENTLGGVCLNVGCIPSKALIQVSENYRTALENEDEGISASDVKLDWAKVQEFRAGVVNKMTNGVSYLFKKNKIDVIHGVAFLKTDHSLRVIDGENAQTYTFKHLIIATGSHPIEIPGFKFGGRVIDSTGVLELKELPKELVIIGGGYIGSELAGAYARFGTHVTILEGTDSILNAYEKDLVKITEKKFKELGVTVITKAMAKEAKDTGDAVEVSYEQDGKVNTIKADYVAVAVGRKPNTKDMGLEQVGIETTDRGLIKVDAQGRTNKEDIFAIGDIVAGAALAHKASYEGKIAAEAIAGQSSVVDYRAMPAVCYVDPEIATTGLTAAQAKEQGLDVKASKFPFSANGRATSKKATDGFVRLVSLKDSGVIVGAQIIGDSASDMISELTLAIESGSTVEDIALTIHPHPSLSEAVMDAADVALGFPTNI

GenBank Info

gene - lpdA
locus_tag - FAM19471-i1-1.1_000883
EC_number - 1.8.1.4
inference - COORDINATES: similar to AA sequence:RefSeq:WP_010495698.1
note - Derived by automated computational analysis using gene prediction method: Protein Homology.
codon_start - 1
transl_table - 11
product - dihydrolipoyl dehydrogenase
protein_id - extdb:FAM19471-i1-1.1_000883

Gene locus (click to toggle display options) expand

Located on scaffold FAM19471-i1-1_scf0013

Update range to 10000 bp

Cellular location expand

Responsible annotations:
SL-0190: GO:0005654 nucleoplasm
SL-0229: GO:0005622 intracellular anatomical structure
SL-0086: GO:0005737 cytoplasm
SL-0173: GO:0005739 mitochondrion
SL-0191: GO:0005634 nucleus
SL-0170: GO:0005759 mitochondrial matrix
SL-0091: GO:0005829 cytosol
SL-0166: GO:0043231 intracellular membrane-bounded organelle
FAM19471-i1-1.1_000882
FAM19471-i1-1.1_000884