update range to 10000 bp
locus tag: FAM19038-p1-1.1_002667 genome: FAM19038-p1-1.1
species: Acidipropionibacterium thoenii DSM 20276 taxid: 1122998

Annotations

Type Name Description Pathways
Gene Product
 bifunctional folylpolyglutamate synthase/dihydrofolate synthase
KEGG reaction
 R04241 tetrahydropteroyl-gamma-polyglutamate:L-glutamate gamma-ligase (ADP-forming); ATP + THF-polyglutamate(n) + L-Glutamate <=> ADP + Orthophosphate + THF-polyglutamate(n+1) kornec01240kornec00790
KEGG reaction
 R02237 7,8-dihydropteroate:L-glutamate ligase (ADP-forming); ATP + Dihydropteroate + L-Glutamate <=> ADP + Orthophosphate + Dihydrofolate kornec01100kornec01240kornec00790
KEGG reaction
 R00942 Tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming); ATP + Tetrahydrofolate + L-Glutamate <=> ADP + Orthophosphate + THF-L-glutamate kornec01240kornec00790
Ortholog
 N0.HOG0000495 bifunctional folylpolyglutamate synthase/dihydrofolate synthase
KEGG gene
 K11754 folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17] kornec01100kornec01240kornec00790
Eggnog Protein
 EP:folC
Eggnog Ortholog
 EO:2GJP2
Eggnog Description
 ED:Mur ligase middle domain
EC Number
 EC:6.3.2.17 tetrahydrofolate synthase; folylpolyglutamate synthase; folate polyglutamate synthetase; formyltetrahydropteroyldiglutamate synthetase; N10-formyltetrahydropteroyldiglutamate synthetase; folylpoly-gamma-glutamate synthase; folylpolyglutamyl synthetase; folylpoly(gamma-glutamate) synthase; folylpolyglutamate synthetase; FPGS; tetrahydrofolylpolyglutamate synthase; tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming); tetrahydropteroyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming) kornec01100kornec00790
EC Number
 EC:6.3.2.12 dihydrofolate synthase; dihydrofolate synthetase; 7,8-dihydrofolate synthetase; H2-folate synthetase; 7,8-dihydropteroate:L-glutamate ligase (ADP); dihydropteroate:L-glutamate ligase (ADP-forming); DHFS kornec01100kornec00790

Occurs in the following pathway maps:

Pathway Description
kornec00790 Folate biosynthesis
kornec01100 Metabolic pathways
kornec01240 Biosynthesis of cofactors

Sequences

Nucleotide sequence (GC-content: 70.9 %):

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CTGCAGGCACGCTGGCCCGAGCACCGGATCGGCCCGGGGCTGGATCGCGAGAGGGCGATCCTGGACCTGCTCGGCAACCCCGAGCGGGCCTACCCGGTGATCCAGGTCGCGGGGACCAATGGCAAGGGGTCCACCGCGATCATGATCGACTCCCTGCTGCGGGCCGCCGGTCTGTGGGTGGGTCGGTACACCTCACCGCACCTGGTGGACCTGCGGGAGCGGATCTGCATCGACGGCGAGCCGGTCGGCGTCGAACGGTTCGATGAGATCTGGGAGCAGATCGCACCGATGGTGCGAATGGTCGACGAGCAGCACATCGACGGCATCGAGCCGACCTTCTTCGAGGTGATGACGGCGATGGCCTTCGCGACCTTCGCCGACACCCCGGTCGACGTCGCGGTGGTCGAGGTGGGCCTGGGGGGCCGGTGGGACGCCACCAACGTGGTCGACGCCCAGGTCGCCGTGGTCGCCCCGGTGGCGATGGACCACATGCACATCCTCGGTGACACGCTGGCCAAGATCGCCGGCGAGAAGGCGGGGATCATCAAGCCGGTGAGCAGCGCGGTGATCGCCGGCCAGAAGCCGGAGGCCGCCCAGGTGCTGCTGGCCCAGTGCGCCGACGTGGGGGTCAAGCCGATCCTCGAGGGGCCGGACTTCGGGCTGCTGGACCGCCGTGGCGCGGTCGGCGGCCAGGTGATCCGGATCCAGACCGCCGGCGGCCCGCTGGGGGAGCTCTTCCTGCCGCTGTTCGGCGAGCACATGGCGCACAACGCCGCCCTGGCGGTGGCCGCCGTGGAGACCTTCATGGGAGGCAAGCCGCTCAACCCCGAGATCATCGAGCAGGGACTGGCCGATGTGGTCGCCCCGGCCCGGCTCGAGGTGGTGCGGCGGACCCCCACCATCGTGCTGGACACCTTCCACAACCCGCACGGTGCGCACTCGGCGATGGCCGGGGTCACCGAGGCCTTCGACCTGAACCCGCTGGTCGCCGTCGTCGCCGCGATGCGCGACAAGGACGTCGACGGGGTGCTCTCGGAGATGTCGGAGGCGGTCGGCCGGGTGGTCCTCACCACCATGCCGGAGCTGCCCCGGGCACTGCCGGTGGCCGAACTCGACGAGATCGCCTCGAAGTACTGGGACGCCGACCACCGGATGACCTGTCCGACGGTCTCCCAGGCCCTCGAGGAGGCGGTCCGGATCGCCGACATGTCCGGCCCCGGTGCCGGCGTGCTCGTCGGCGGGTCGGCGGTGCTGGCCGGCCAGGCCAGAGCCATCCTGGTGCCCGACGGGATCAATCACGTCCATGCCGGGCCGCAGGCGGTGGTGGAGACCCCTCAGCTGTCCGAGGAGCAGATCGCCGCCATGGAGGGGGAGGTTCTCGAGCCCGTCGAGGAGGATCCCACCGACGGCGACGAGGAGTCCTGGTGA

Protein sequence:

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MQARWPEHRIGPGLDRERAILDLLGNPERAYPVIQVAGTNGKGSTAIMIDSLLRAAGLWVGRYTSPHLVDLRERICIDGEPVGVERFDEIWEQIAPMVRMVDEQHIDGIEPTFFEVMTAMAFATFADTPVDVAVVEVGLGGRWDATNVVDAQVAVVAPVAMDHMHILGDTLAKIAGEKAGIIKPVSSAVIAGQKPEAAQVLLAQCADVGVKPILEGPDFGLLDRRGAVGGQVIRIQTAGGPLGELFLPLFGEHMAHNAALAVAAVETFMGGKPLNPEIIEQGLADVVAPARLEVVRRTPTIVLDTFHNPHGAHSAMAGVTEAFDLNPLVAVVAAMRDKDVDGVLSEMSEAVGRVVLTTMPELPRALPVAELDEIASKYWDADHRMTCPTVSQALEEAVRIADMSGPGAGVLVGGSAVLAGQARAILVPDGINHVHAGPQAVVETPQLSEEQIAAMEGEVLEPVEEDPTDGDEESW

GenBank Info

locus_tag - FAM19038-p1-1.1_002667
inference - COORDINATES: similar to AA sequence:RefSeq:WP_002531002.1
note - Derived by automated computational analysis using gene prediction method: Protein Homology.
codon_start - 1
transl_table - 11
product - bifunctional folylpolyglutamate synthase/dihydrofolate synthase
protein_id - extdb:FAM19038-p1-1.1_002667

Gene Locus

Located on scaffold FAM19038-p1-1_scf0001

FAM19038-p1-1.1_002666
FAM19038-p1-1.1_002668