locus tag: FAM19038-p1-1.1_002552 genome: FAM19038-p1-1.1
species: Acidipropionibacterium thoenii DSM 20276 taxid: 1122998

Annotations

Type Name Description Pathways
Gene Code
 leuA
KEGG reaction
 R01213 acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming); 3-Carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating); alpha-Isopropylmalate + CoA <=> Acetyl-CoA + 3-Methyl-2-oxobutanoic acid + H2O kornec00290 kornec01230 kornec01100 kornec00620 kornec01110 kornec01210
Ortholog
 N0.HOG0001618 2-isopropylmalate synthase
KEGG gene
 K01649 leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13] kornec00290 kornec01230 kornec01100 kornec00620 kornec01110 kornec01210
Eggnog Protein
 EP:leuA
Eggnog Ortholog
 EO:2GISX
Eggnog Description
 ED:Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EC Number
 EC:2.3.3.13 2-isopropylmalate synthase; 3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating); alpha-isopropylmalate synthetase; alpha-isopropylmalate synthase; alpha-isopropylmalic synthetase; isopropylmalate synthase; isopropylmalate synthetase kornec00290 kornec01100 kornec00620 kornec01110
Gene Product
 2-isopropylmalate synthase

Occurs in the following pathway maps:

Pathway Description
kornec00290 Valine, leucine and isoleucine biosynthesis
kornec00620 Pyruvate metabolism
kornec01100 Metabolic pathways
kornec01110 Biosynthesis of secondary metabolites
kornec01210 2-Oxocarboxylic acid metabolism
kornec01230 Biosynthesis of amino acids

Sequences

Nucleotide sequence (GC-content: 67.3 %):

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ATGACCCGCCCACAGTCCTCACCCTGCCAGTTGACCTCACCGATGCCGGTCGACCGCTACAAGCCCTTCATCCCGCAGTCGCTGCCCGATCGCACCTGGCCCGACAAGACCCTCGACAAGGCACCCCGATGGCTGTCGACCGATCTGCGCGACGGCAACCAGGCCCTGATCGACCCGATGACCGTCTCGCGCAAGGTGCGGATGTTCAACCTGCTCATCGAGATGGGCTACAAGGAGATCGAGATCGGCTTCCCCTCGGCCTCCCAGACCGAGTACGACTTCGTGCGCAAGCTGATCGAGGAGGACGTCGTTCCCGACGACGTCACGATCTCGGTGCTGACCCAGGCCCGCGAGGACCTCATCCGCCGCACCGCGCAGAGCCTGGTCGGCGCCCACCGCGCCACCATCCACATGTACAACGCGACCGCCGAGCTGTTCCGCCGGGTGGTCTTCCACGTCAACGAGCAGCAGTGCATCGACCTGGCCCACCAGGGCACCGAATGGGTCGTCAAGTACGCCGAGGAGTACCTGGACGACGTCGAGTTCGGTTACGAGTACTCCCCGGAGATCTTCACCCAGACCCCGACCGACTTCGCCCTGGAGGTGTGCGAGTCGGTGATGGACGTCTGGCAGCCCGCCGAGGGCCGCGAGATCATCCTCAACCTGCCCGCCACCGTGGAGATGAGCACCCCGAACACCTTCGGCGACCAGATCGAGTACTTCTGCCGCAACATCCGCGACCGCCAGCACGTGTGCGTCTCGGTGCACCCCCACAACGACCGGGGTACCGGCGTCGCGGCCGCCGAGTTCGCCCAGATGGCCGGCGCCGACCGGGTCGAGGGATGCCTCTTCGGCCACGGCGAGAGAACCGGCAATGTCGACCTGGTCACCCTGGGGATGAACCTGTTCAGCCAGGGCGTCGACCCGAAGATCGACTTCTCCGACATGCCCCAGATCCGCCGCACCGTCGAGTACTGCACCGGGCTGCCGGTGCCGGCCCGCCAGCCCTACTCCGGCGACCTGGTCTTCACCGCCTTCTCCGGCTCCCACCAGGACGCCATCAAGAAGGGCCTGGAGGACCTGCAGCGGATCGCCGACGAGCAGGGCGTCGATGAGCGCAAGGTGACCTGGCAGGCCCCCTACCTGGCCGTCGACCCGCACGACATCGGCCGCACCTACGAGGCCGTCATCCGCGTCAACAGCCAGTCCGGCAAGGGCGGGATGGCCTACCTGATGAAGACCGAGCACCAGGTGGACCTGCCCCGGCGTCTGCAGATCGAGTTCTCCAAGTCGGTGCAGTTCCTCACCGACCAGGAGGCCCGCGAGATCAGCCACGACGAGATCTGGGACCTGTTCTCCCGGGAGTACCTTCACACCGACGGGATCCAGCTGGTCTCCCGCGAGTCCGCCACCCGCGGGGGCAGTCACGAGATCACCGCGACGATCGGGGTCGACGGCGCCCAGCGCACCATCTCCGGTGAAGGCAACGGCGCGGTCTCGGCCTTCGTCGACGCCCTGGACTCGCTCGGCGTGGTCGTCCACGTGCTGGACTACTCCGAGCACGCGATGACCGCAGGCGGCACCGCGAAGGCCGCCGCCTATGTGGAGTGCGAGGTCGGCGACGGGGAGTCCAGCCAGATCCTGTGGGGTGTCGGCATCGACTCCGACATCACCGAGGCCTCTCTCAAGGCGGTCATCGGGGCCGTCAACCGGTCCGGCGCGAGGGTGCAGGTCGACGAACGGGTCGGTTCCCGACAGGGCTGA

Protein sequence:

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MTRPQSSPCQLTSPMPVDRYKPFIPQSLPDRTWPDKTLDKAPRWLSTDLRDGNQALIDPMTVSRKVRMFNLLIEMGYKEIEIGFPSASQTEYDFVRKLIEEDVVPDDVTISVLTQAREDLIRRTAQSLVGAHRATIHMYNATAELFRRVVFHVNEQQCIDLAHQGTEWVVKYAEEYLDDVEFGYEYSPEIFTQTPTDFALEVCESVMDVWQPAEGREIILNLPATVEMSTPNTFGDQIEYFCRNIRDRQHVCVSVHPHNDRGTGVAAAEFAQMAGADRVEGCLFGHGERTGNVDLVTLGMNLFSQGVDPKIDFSDMPQIRRTVEYCTGLPVPARQPYSGDLVFTAFSGSHQDAIKKGLEDLQRIADEQGVDERKVTWQAPYLAVDPHDIGRTYEAVIRVNSQSGKGGMAYLMKTEHQVDLPRRLQIEFSKSVQFLTDQEAREISHDEIWDLFSREYLHTDGIQLVSRESATRGGSHEITATIGVDGAQRTISGEGNGAVSAFVDALDSLGVVVHVLDYSEHAMTAGGTAKAAAYVECEVGDGESSQILWGVGIDSDITEASLKAVIGAVNRSGARVQVDERVGSRQG

GenBank Info

gene - leuA
locus_tag - FAM19038-p1-1.1_002552
EC_number - 2.3.3.13
inference - COORDINATES: similar to AA sequence:RefSeq:WP_016667432.1
note - Derived by automated computational analysis using gene prediction method: Protein Homology.
codon_start - 1
transl_table - 11
product - 2-isopropylmalate synthase
protein_id - extdb:FAM19038-p1-1.1_002552

Gene locus (click to toggle display options) expand

Located on scaffold FAM19038-p1-1_scf0001

Update range to 10000 bp
FAM19038-p1-1.1_002551
FAM19038-p1-1.1_002553